RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0503
Feature Type Riboswitch
Name Thiamine pyrophosphate riboswitch
Regulatory Motif
(RNAMotif descriptor)
descr

	h5(minlen=3, maxlen=7)

		h5(len=4)

			ss(seq="^G$")

			ss(len=1)

			h5(len=2)

				ss(len=3)

			h3

			ss(seq="^CUGAGA$")

			ss(minlen=1, maxlen=4)

			ss(seq="^A$")

		h3

		ss(len=2)

		ss(seq="^GAA$")

		h5(seq="^CCU$")

			ss(seq="^GAU$")

			h5(len=4, seq="G$")

				ss(len=1)

				ss(seq="^U$")

				ss(len=4)

			h3

			ss(seq="^CGD$")

		h3

		ss(seq="^RA$")

	h3
Ligand TPP (thiamin pyrophosphate)
References Winkler W, Nahvi A, and Breaker RR
Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression.
Nature 2002; 419(6910), 952-6   PubMed 

Sudarsan N, Barrick JE, and Breaker RR
Metabolite-binding RNA domains are present in the genes of eukaryotes.
RNA 2003; 9(6), 644-7   PubMed 

Winkler WC, and Breaker RR
Genetic control by metabolite-binding riboswitches.
Chembiochem 2003; 4(10), 1024-32   PubMed 

Mandal M, and Breaker RR
Gene regulation by riboswitches.
Nat Rev Mol Cell Biol 2004; 5(6), 451-63   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang