RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0040
Feature Type RegRNA in 5'-UTR
Name Renin stability regulatory element (Ren_SRE)
Regulatory Motif
descr

	ss(seq="^UK$")

	ss(minlen=0, maxlen=1)

	ss(seq="^CUUU$")

	ss(seq="^RRGGRM$")

	ss(minlen=0, maxlen=3)

	ss(seq="^AAA$")

	ss(minlen=0, maxlen=4)

	ss(seq="^AUAAAGAYUNCAUGUU")

Description Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, inducing the production of angiotensin II and initiating a cascade of reactions that results in an elevation of blood pressure and increased sodium retention by the kidney. Renin (REN) mRNA stability is modulated by a cis-acting element, about 35 nt long, located in the 3’UTR. This element, that contributes to basal REN mRNA instability, is the target of a number of mRNA binding proteins that destabilize (HADHB) or stabilize (HuR, CP1) REN mRNA regulating rennin production.
References
HADHB, HuR, and CP1 bind to the distal 3 -untranslated region of human renin mRNA and differentially modulate renin expression.
J Biol Chem 2003; , 44894-903   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang