||RegRNA in 5'-UTR
||Myelin Basic Protein Localization Element (MBP-A2RE11)
||Localization of myelin basic protein (MBP) mRNA to the myelin compartment in oligodendrocytes requires a short sequence element - whose core element is 11 nt long - located in the 3'UTR and interacting with heterogeneous nuclear protein A2 (hnRNP A2). Oligodendrocyte transport occurs via mRNA packaging into granules in the nucleus followed by export to cytoplasm and then microtubule- or microfilament-mediated transport to the final destination.
Transport and localization elements in myelin basic protein mRNA.
J Cell Biol 1997; , 1077-87   PubMed