RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0037
Feature Type RegRNA in 5'-UTR
Name Myelin Basic Protein Localization Element (MBP-A2RE11)
Regulatory Motif
descr

	ss(seq="^GSWCACY$")

	ss(seq="^GCCAWGGAGSC$")

	ss(seq="^ASASAGC$")

Description Localization of myelin basic protein (MBP) mRNA to the myelin compartment in oligodendrocytes requires a short sequence element - whose core element is 11 nt long - located in the 3'UTR and interacting with heterogeneous nuclear protein A2 (hnRNP A2). Oligodendrocyte transport occurs via mRNA packaging into granules in the nucleus followed by export to cytoplasm and then microtubule- or microfilament-mediated transport to the final destination.
References
Transport and localization elements in myelin basic protein mRNA.
J Cell Biol 1997; , 1077-87   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang