||RegRNA in 5'-UTR
||Drosophila hairy mRNA localization element (HLE)
wc += gu;
||In the early embryo of drosophila several transcripts localize exclusively apically of the peripheral nuclei. Apical transport of hairy pair-rule mRNA is mediated by a 121 nt element located in the 3’ untranslated region. This element comprises two stem-loop structures in which double-stranded stems have been observed to be essential for localization. Base pair identities within the stem are not essential but contribute to the efficiency of localization thus suggesting that specificity is mediated by higher-order structure.
The Drosophila hairy RNA localization signal modulates the kinetics of cytoplasmic mRNA transport.
EMBO J 2003; , 2484-94   PubMed