RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0036
Feature Type RegRNA in 5'-UTR
Name Drosophila hairy mRNA localization element (HLE)
Regulatory Motif
parms

	wc += gu;


descr

	h5(seq="^CAUUUC$")

		ss(seq="^ACNN$")

	h5(seq="^CAUU$")

		ss(minlen=0, maxlen=1)

		ss(seq="^CG$")

		ss(seq="^CCRGGAUNN$")

		ss(seq="^CGCN$")

	h3

		ss(seq="^UUGNUU$")

		ss(minlen=0, maxlen=2)

	h3

Description In the early embryo of drosophila several transcripts localize exclusively apically of the peripheral nuclei. Apical transport of hairy pair-rule mRNA is mediated by a 121 nt element located in the 3 untranslated region. This element comprises two stem-loop structures in which double-stranded stems have been observed to be essential for localization. Base pair identities within the stem are not essential but contribute to the efficiency of localization thus suggesting that specificity is mediated by higher-order structure.
References
The Drosophila hairy RNA localization signal modulates the kinetics of cytoplasmic mRNA transport.
EMBO J 2003; , 2484-94   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang