RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0031
Feature Type RegRNA in 5'-UTR
Name CaMKII/Ng dendritic localization element (CNDLE)
Regulatory Motif
descr

	ss(seq="^YRGGRNC$")

	ss(minlen=0, maxlen=4)

	ss(seq="^CS$")

	ss(minlen=6, maxlen=10)

	ss(seq="^CSCAGAGA$")

	ss(minlen=0, maxlen=1)

	ss(seq="^TCC$")

	ss(minlen=0, maxlen=1)

	ss(seq="^YTCW$")

	ss(minlen=2, maxlen=8)

	ss(seq="^WGG$")

Description Alpha subunit of calcium calmodulin dependent kinase II (CaMKII) protein, highly enriched at synapse is important in synaptic plasticity, learning and long-term memory. The 5’ part (nt 1-94) of 3’UTR of CaMKII mRNA mediates its dendritic targeting. An inhibitory element located downstream in the 3’UTR prevents CaMKII mRNA transport into dendrites. Prolonged depolarization override transport repression thus suggesting an anctivity-sensitive interaction between the two control elements. A similar dendritic localization element has been found to be active in the 3’UTR of neurogranin (Ng) mRNA, coding for a neuronal specific calmodulin binding protein. The minimal targeting signal denoted as CaMKII/Ng dendritic localization element (CNDLE) corresponds to a highly conserved 28-nt region.
References Mori Y, Imaizumi K, Katayama T, Yoneda T, and Tohyama M
Two cis-acting elements in the 3 untranslated region of alpha-CaMKII regulate its dendritic targeting.
Nat Neurosci 2000; 3(11), 1079-84   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang