RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0030
Feature Type RegRNA in 5'-UTR
Name Gap-43 Stabilization Element (GAP-43)
Regulatory Motif
guccacuuuccu yyyyyy[0,6,0] muyucucucug
Description The expression of Growth Associated Protein (GAP-43) involved in neurite outgrowth is post-trascriptionally regulated by a highly conserved 23-29 nt long sequence in the mRNA 3'UTR. The interaction of this element with the ELAV-like RNA binding protein HuD results in the increased stability of gap-43 transcript.
References Kohn DT, Tsai KC, Cansino VV, Neve RL, and Perrone-Bizzozero NI
Role of highly conserved pyrimidine-rich sequences in the 3 untranslated region of the GAP-43 mRNA in mRNA stability and RNA-protein interactions.
Brain Res Mol Brain Res 1996; 36(2), 240-50   PubMed 

Chung S, Eckrich M, Perrone-Bizzozero N, Kohn DT, and Furneaux H
The Elav-like proteins bind to a conserved regulatory element in the 3 -untranslated region of GAP-43 mRNA.
J Biol Chem 1997; 272(10), 6593-8   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang