RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0027
Feature Type RegRNA in 5'-UTR
Name Elastin G3A 3'UTR stability motif (G3A)
Regulatory Motif
tgnn p1=rrrrrrrrrrrrrrrrrrr[1,3,0]

p1:(ggga ggga 0...3 ggga 0...1 ggg)
Description Developmental regulation of elastin synthesis occurs through modulation of the stability of its mRNA. It has been demonstrated that the binding of cytosolic proteins to a large region of the 3'UTR of elastin mRNA, possibly folded into a stable secondary structure, is associated to stabilization/destabilization of elastin mRNA. Using deletion and competition analyses the core cis-acting sequence has been mapped to a 20 nt long purine rich sequence containing at least a 3-fold repeat of GGGA (G3A) motif conserved from human to chicken.
References Hew Y, Lau C, Grzelczak Z, and Keeley FW
Identification of a GA-rich sequence as a protein-binding site in the 3 -untranslated region of chicken elastin mRNA with a potential role in the developmental regulation of elastin mRNA stability.
J Biol Chem 2000; 275(32), 24857-64   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang