RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0026
Feature Type RegRNA in 5'-UTR
Name Androgen receptor GU-rich element (AR_CURE)
Regulatory Motif
descr

	ss(seq="^CUGGG$")

	ss(minlen=10, maxlen=40)

	ss(seq="^CCCUCCC$")

Description The androgen receptor mRNA contains a highly conserved UC-rich region in the 3'-untranslated region that are the target of HuR and CP1/CP2 RNA binding proteins imvolved in the regulation of mRNA stability and translation initiation. Mutational analysis has shown that HuR (also binding AU-rich motifs) binds to the U-rich portion of the UC-rich region whereas CP1 and CP2 bind to the C-rich portion. A model of cooperative binding of HuR and CPs is proposed with binding disruption resulting in transcript destabilization.
References Yeap BB, Voon DC, Vivian JP, McCulloch RK, Thomson AM, Giles KM, Czyzyk-Krzeska MF, Furneaux H, Wilce MC, Wilce JA, and Leedman PJ
Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3 -untranslated region of the androgen receptor messenger RNA.
J Biol Chem 2002; 277(30), 27183-92   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang