A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006

Accession R0025
Feature Type RegRNA in 5'-UTR
Name GY-Box (GY)
Regulatory Motif


Description Many Notch pathway target genes in Drosophila, including most members of the basic helix-loop-helix repressor family and the Bearded family, contain a series of conserved sequence motifs in their 3' UTRs, including the Brd box, the K box, and the GY box. The GY box (GTCTTCC) is present in one or more copies in several of these 3' UTRs, but does not appear to have strong cis-regulatory activity. However, its function likely involves the formation of RNA duplexes with (1) a complementary sequence found in the 3' UTRs of proneural basic helix-loop-helix genes (the proneural box, ATGGAAGACAAT) and (2) with complementary sequences found at the 5' ends of certain micro RNAs (miRNAs).
References Lai EC, Bodner R, Kavaler J, Freschi G, and Posakony JW
Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes.
Development 2000; 127(2), 291-306   PubMed 

Lai EC
Micro RNAs are complementary to 3 UTR sequence motifs that mediate negative post-transcriptional regulation.
Nat Genet 2002; 30(4), 363-4   PubMed 

Lai EC, Burks C, and Posakony JW
The K box, a conserved 3 UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts.
Development 1998; 125(20), 4077-88   PubMed 

Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang