A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006

Accession R0024
Feature Type RegRNA in 5'-UTR
Name Brd-Box (Brd)
Regulatory Motif


Description Many Notch pathway target genes in Drosophila, including most members of the basic helix-loop-helix repressor family and the Bearded family, contain a series of conserved sequence motifs in their 3' UTRs, including the Brd box, the K box, and the GY box. The Brd box (AGCTTTA) is present in one or more copies in many of these 3'UTRs and mediates negative post-transcriptional regulation by affecting transcript stability and translational efficiency. Regulation by the Brd box is spatially and temporally ubiquitous, and likely involves the formation of RNA-RNA duplexes with complementary sequences found at the 5'end of certain micro RNAs (miRNAs). Brd box-complementary miRNAs are also found in other nematodes, suggestive of functional conservation.
References Lai EC
Micro RNAs are complementary to 3 UTR sequence motifs that mediate negative post-transcriptional regulation.
Nat Genet 2002; 30(4), 363-4   PubMed 

Lai EC, Burks C, and Posakony JW
The K box, a conserved 3 UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts.
Development 1998; 125(20), 4077-88   PubMed 

Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang