RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0020
Feature Type RegRNA in 5'-UTR
Name Alcohol dehydrogenase 3'UTR downregulation control element (ADH_DRE)
Regulatory Motif
descr

	ss(seq="^AAGGCTGA$")

Description A highly conserved eight base sequence within the 3' untranslated region of the Drosophila Alcohol dehydrogenase (Adh) mRNA, identified by phylogenetic analysis, was found to produce a two-fold downregulation of Adh gene expression. The experimental assay was carried out by in vitro deletion mutagenesis followed by P element mediated germline transformation. Downregulation was found to be the result of a temporally and spatially generated decrease in the Adh transcript possibly resulting by either a reduction of transcription rate or most likely by a reduction of the mRNA stability.
References Parsch J, Russell JA, Beerman I, Hartl DL, and Stephan W
Deletion of a conserved regulatory element in the Drosophila Adh gene leads to increased alcohol dehydrogenase activity but also delays development.
Genetics 2000; 156(1), 219-27   PubMed 

Parsch J, Stephan W, and Tanda S
A highly conserved sequence in the 3 -untranslated region of the drosophila Adh gene plays a functional role in Adh expression.
Genetics 1999; 151(2), 667-74   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang