RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0019
Feature Type RegRNA in 5'-UTR
Name Bruno 3'UTR responsive element (BRE)
Regulatory Motif
p1=wuurururuu[1,0,0]  p1:(p2=wnurururu) p1:(nngngng[2,0,0]) 0...3

p3=wuurururuu[1,0,0]  p3:(p4=wnurururu) p3:(nngngng[2,0,0])
Description The posterior localization of oskar protein in the posterior pole of drosophila embryos is requested to direct the deployment of nanos, the posterior body patterning morphogen in Drosophila. The regulation mechanism involves translation repression of oskar mRNA prior to its localization at the posterior pole of the oocyte. Translation repression is mediated by the ovarian protein bruno that binds specifically to a cis-acting element located in the the 3’UTR of the oskar mRNA made by a tandem repetition of a 10 nt long consensus sequence.
References Castagnetti S, Hentze MW, Ephrussi A, and Gebauer F
Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries.
Development 2000; 127(5), 1063-8   PubMed 

Kim-Ha J, Kerr K, and Macdonald PM
Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential.
Cell 1995; 81(3), 403-12   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang