RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0013
Feature Type RegRNA in 5'-UTR
Name Tumor necrosis factor alpha 3'UTR cis-acting element(TNF)
Regulatory Motif
descr

	ss(seq="^UUAUGUUU$")

	ss(minlen=0, maxlen=8)

	ss(seq="^AR$")

	ss(seq="^AUAUUUAU$")

	ss(seq="^SURAYYNRRU$")

	ss(seq="^UGUCW$")

Description Tumor necrosis factor alpha (TNF-alpha) is a key cytokine regulator of the immune process and of the tissue homeostasis. The production of TNF-alpha is mainly controlled post-trascriptionally by cis-elements located in the 3'-UTR and which regulate mRNA stability and translation efficency. In addition to a class II AU-rich element (ARE2) previously found in the 3'-UTR of TNF-alpha mRNA, another RNA binding motif has been characterized about 150 nt downstream. This element contains a consensus core of AUAUUUA, which is highly conserved in evolution, and has been suggested to synergize with the ARE2 element in the repression of TNF-alpha mRNA translation and in the regulation of translation.
References Hel Z, Di Marco S, and Radzioch D
Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3 -UTR of TNF-alpha mRNA.
Nucleic Acids Res 1998; 26(11), 2803-12   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang