RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0012
Feature Type RegRNA in 5'-UTR
Name Glusose transporter type-1 3'UTR cis-acting element(GLUT1)
Regulatory Motif
descr

	ss(seq="^CCAACCACTC$")

Description The 5' and 3' untranslated (UTR) regions of the Na+ independent glucose transporter GLUT1 mRNA are highly conserved among species being embedded of several cis-acting regulatory elements which either stabilize or destabilize the mRNA subsequent to the binding of specific cytosolic or polysome proteins in response to glucose deprivation or to brain derived trophic factors. A 10 nucleotide cis-acting element, located in the GLUT1 3'-UTR region, has been shown to increase GLUT1 gene expression via specific binding to a 80 kDa protein, expressed in human brain hemangioblastoma and in the C6 rat brain glioma, which mediates mRNA stabilization.
References Boado RJ, and Pardridge WM
Ten nucleotide cis element in the 3 -untranslated region of the GLUT1 glucose transporter mRNA increases gene expression via mRNA stabilization.
Brain Res Mol Brain Res 1998; 59(1), 109-13   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang