RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0010
Feature Type RegRNA in 5'-UTR
Name AU-rich class-2 Element (ARE2)
Regulatory Motif
wwwwwwwwwwwwwwwwwwww[8,0,0]

p1=auuu p2=0...4 p1 p3=0...4 p1 p4=0...4 p1 

p1/p2/p1/p3/p1/p4/p1:(p5=auuuauuua)
Description AU-rich elements (AREs) present in the 3'untranslated region of mature lymphokine and cytokine mRNAs regulate mRNA stability and translational efficiency. Based on their sequence features and functional properties AREs can be divided into three classes. Class II AREs direct asynchronous cytoplasmic deadenylation (processive kinetics) generating poly-A(-) mRNAs. Among mRNA with class II ARE in their 3' UTR are GM-CSF, IL-2.The minimum number of AUUUA tandem motifs to activate processive degradation is 4 (of which at least 3 in tandem). Furthermore, an AU-rich region 20-30 nt long immediately 5' to the cluster of AUUUA motifs can greatly enhance the degradation activity.
References Chen CY, and Shyu AB
AU-rich elements: characterization and importance in mRNA degradation.
Trends Biochem Sci 1995; 20(11), 465-70   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang