A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006

Accession R0009
Feature Type RegRNA in 5'-UTR
Name 15-Lipoxygenase Differentiation Control Element (15-LOX-DICE)
Regulatory Motif
20 > repeat (cccyryccucy[1,1,0] p1=1...7 ang) 0...0 > 1
Description Erythroid 15-lipoxygenase (15-LOX) synthesized in the early stages of erytropoiesis catalyses the degradation of lipids and is an important factor responsible for the degradation of mitochondria during reticulocyte maturation. The 3'UTR of 15-LOX mRNA contains tandem repeat sequences, referred to as "DICE" for "DIfferentiation Control Element" which specifically bind to regulatory proteins, formerly called LOX-BP. This binding specifically inhibits 15-LOX mRNA translation. In rabbit 15-LOX mRNA, there have been found 10 tandem copies of the repeat sequence, but only 4 (3 tandem) in human. Experimentally, a functional DICE consisting of two repeat elements has been described. The regulatory binding proteins have been identified as hnRNP K and hnRNP E1.
References Ostareck-Lederer A, Ostareck DH, Standart N, and Thiele BJ
Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3 untranslated region.
EMBO J 1994; 13(6), 1476-81   PubMed 

Ostareck DH, Ostareck-Lederer A, Wilm M, Thiele BJ, Mann M, and Hentze MW
mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3 end.
Cell 1997; 89(4), 597-606   PubMed 

Ostareck-Lederer A, Ostareck DH, and Hentze MW
Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1/E2.
Trends Biochem Sci 1998; 23(11), 409-11   PubMed 

Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang