RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0008
Feature Type RegRNA in 5'-UTR
Name Nanos translation control element (NANOS_TCE)
Regulatory Motif
parms

	wc += gu;


descr

	h5(minlen=4, maxlen=10)

		h5(minlen=6, maxlen=9)

			ss(seq="^CUGGC$")

		h3

		ss(minlen=0, maxlen=3)

		h5(minlen=10, maxlen=12, mispair=1)

			ss(minlen=7, maxlen=8)

		h3

		ss(minlen=0, maxlen=2)

	h3

	
Description The 3'UTR of drosophila nanos mRNA contains the essential signals for generating the nanos gradient emanating from the posterior pole of drosophila embryos. The polarized distribution of nanos is generated by the localization dependent translation of nanos mRNA in the pole plasm. The translation control element (TCE) consist of a 90-nt region located in the 3'UTR of nanos mRNA which is able to fold into a bipartite secondary structure that is recognized by Smaug repressor and at least one additional factor. A stem-loop bearing the CUGGC penramer in the loop is required for Smaug TCE unteractionn whereas both sequences and structure of another stem-loop is critical for TCE function.The translation activation is mediated by the interaction of localization factors with a 540-nt sequence regions overlapping the TCE structural motif.
References Crucs S, Chatterjee S, and Gavis ER
Overlapping but distinct RNA elements control repression and activation of nanos translation.
Mol Cell 2000; 5(3), 457-67   PubMed 

Gavis ER, Lunsford L, Bergsten SE, and Lehmann R
A conserved 90 nucleotide element mediates translational repression of nanos RNA.
Development 1996; 122(9), 2791-800   PubMed 

Dahanukar A, and Wharton RP
The Nanos gradient in Drosophila embryos is generated by translational regulation.
Genes Dev 1996; 10(20), 2610-20   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang