RegRNA
A Regulatory RNA Motifs and Elements Finder
  Release 1.0, Jan 2006
 
 
 

Accession R0006
Feature Type RegRNA in 5'-UTR
Name Cytoplasmic polyadenylation element (CPE)
Regulatory Motif
descr

	ss(seq="^UUUUUWAU$")

	ss(minlen=1, maxlen=9999)

	ss(seq="^AAUAAA$")

	ss(minlen=1, maxlen=100)

Description Cytoplasmic polyadenylation is an evolutionarily conserved mechanism regulating translational activation of a set of quiescent maternal messenger RNAs (mRNAs) during early development. Cytoplasmic poly(A) elongation occurs in a wide range of species, ranging from clam to mouse. The relevance of this process during late oogenesis and early embryogenesis has been shown by studies in the mouse, Xenopus, and Drosophila. In mouse and Xenopus, the only vertebrates so far examined, the critical regulatory sequences, referred to as Cytoplasmic Polyadenylation Elements (CPEs), are AU-rich and located in the 3' untranslated region (3'-UTR) near the canonical nuclear polyadenylation element (AAUAAA), which also is required for proper poly(A) addition. The CPE has the general structure of UUUUUUAU. However, the CPE is not identical in all mRNAs and its position varies relative to AAUAAA (generally within 100 nucleotides). The minimal CPE capable to stimulate elongation of a poly(A) tail appears to be UUUUAU, and recent experiments show also the existence of substantial context and position effects on CPE function.
References Vassalli JD, and Stutz A
Translational control. Awakening dormant mRNAs.
Curr Biol 1995; 5(5), 476-9   PubMed 

Verrotti AC, Thompson SR, Wreden C, Strickland S, and Wickens M
Evolutionary conservation of sequence elements controlling cytoplasmic polyadenylylation.
Proc Natl Acad Sci U S A 1996; 93(17), 9027-32   PubMed 


Department of Biological Science and Technology, Institute of Bioinformatics, National Chiao Tung University, Taiwan
Contact with Dr. Hsien-Da Huang